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Faster tissue regeneration Reprogramming cellular bioenergetics repairs rabbit bone defects Dr. Gaojie Yang, Huazhong University of Science and Technology Nanoparticles fight tumors Nanoparticle exposure induces breast cancer tumor suppression in mice NCI/Case Western Reserve University/Science Source Wood-based bioenergy Wood-based bioenergy plus climate policies may help curb emissions Wayne Hutchinson/Farm Images/Universal Images Group via Getty Images Porous organic electronics A low-cost, nature-inspired approach to organic electronic technology Binghao Wang Contents March 2020 Vol 6, Issue 13 Contents Research Articles DUSP6 SUMOylation protects cells from oxidative damage via direct regulation of Drp1 dephosphorylation By Ruining Ma , Lina Ma , Weiji Weng , Yingping Wang , Huiqing Liu , Rongjun Guo , Yingwei Gao , Jun Tu , Tian-Le Xu , Jinke Cheng , Michael X. Zhu , Aiwu Zhou , Yong Li 25 Mar 2020 : eaaz0361 Open Access CCBY-NC Our work uncovers a novel SUMOylation-dependent regulation of DUSP6 stability and its activity, which regulates Drp1 function. Abstract Full Text PDF Supplementary Materials Extreme cavity expansion in soft solids: Damage without fracture By Jin Young Kim , Zezhou Liu , Byung Mook Weon , Tal Cohen , Chung-Yuen Hui , Eric R. Dufresne , Robert W. Style 27 Mar 2020 : eaaz0418 Open Access CCBY Cavities in soft materials grow like voids in ductile metals. Abstract Full Text PDF Supplementary Materials A novel physical mechanism of liquid flow slippage on a solid surface By Yuji Kurotani , Hajime Tanaka 27 Mar 2020 : eaaz0504 Open Access CCBY-NC We show how shear flow enhances the density fluctuation of a liquid near the wall and leads to flow slippage. Abstract Full Text PDF Supplementary Materials Breath figure–derived porous semiconducting films for organic electronics By Xinan Zhang , Binghao Wang , Lizhen Huang , Wei Huang , Zhi Wang , Weigang Zhu , Yao Chen , YanLi Mao , Antonio Facchetti , Tobin J. Marks 25 Mar 2020 : eaaz1042 Open Access CCBY-NC We show here that breath figure–derived semiconducting films are suitable and universal for porous organic electronics. Abstract Full Text PDF Supplementary Materials Atomic-scale insights into the interfacial instability of superlubricity in hydrogenated amorphous carbon films By Xinchun Chen , Xuan Yin , Wei Qi , Chenhui Zhang , Junho Choi , Sudong Wu , Rong Wang , Jianbin Luo 27 Mar 2020 : eaay1272 Open Access CCBY-NC Atomic-scale characterization reveals the origins of oxygen- and moisture-induced structural instability of superlubricity. Abstract Full Text PDF Supplementary Materials Chemical boundary engineering: A new route toward lean, ultrastrong yet ductile steels By Ran Ding , Yingjie Yao , Binhan Sun , Geng Liu , Jianguo He , Tong Li , Xinhao Wan , Zongbiao Dai , Dirk Ponge , Dierk Raabe , Chi Zhang , Andy Godfrey , Goro Miyamoto , Tadashi Furuhara , Zhigang Yang , Sybrand van der Zwaag , Hao Chen 27 Mar 2020 : eaay1430 Open Access CCBY-NC Chemical boundary engineering expands the dimensionality of alloy design. Abstract Full Text PDF Supplementary Materials Nanoparticle interactions with immune cells dominate tumor retention and induce T cell–mediated tumor suppression in models of breast cancer By Preethi Korangath , James D. Barnett , Anirudh Sharma , Elizabeth T. Henderson , Jacqueline Stewart , Shu-Han Yu , Sri Kamal Kandala , Chun-Ting Yang , Julia S. Caserto , Mohammad Hedayati , Todd D. Armstrong , Elizabeth Jaffee , Cordula Gruettner , Xian C. Zhou , Wei Fu , Chen Hu , Saraswati Sukumar , Brian W. Simons , Robert Ivkov 25 Mar 2020 : eaay1601 Open Access CCBY-NC Systemic exposure to nanoparticles induces immune responses that lead to anticancer immune activation. Abstract Full Text PDF Supplementary Materials Coordinated regulation of infection-related morphogenesis by the KMT2-Cre1-Hyd4 regulatory pathway to facilitate fungal infection By Yiling Lai , Xuan Cao , Jingjing Chen , Lili Wang , Gang Wei , Sibao Wang 25 Mar 2020 : eaaz1659 Open Access CCBY-NC The KMT2-Cre1-Hyd4 regulatory pathway modulates infection-related morphogenesis and pathogenicity in an insecticidal fungus. Abstract Full Text PDF Supplementary Materials How to run 50% faster without external energy By Amanda Sutrisno , David J. Braun 25 Mar 2020 : eaay1950 Open Access CCBY-NC The hidden potential of human performance augmentation via unpowered robotic exoskeletons. Abstract Full Text PDF Supplementary Materials SKP1 drives the prophase I to metaphase I transition during male meiosis By Yongjuan Guan , N. Adrian Leu , Jun Ma , Lukáš Chmátal , Gordon Ruthel , Jordana C. Bloom , Michael A. Lampson , John C. Schimenti , Mengcheng Luo , P. Jeremy Wang 25 Mar 2020 : eaaz2129 Open Access CCBY-NC SKP1 coordinates chromosome synapsis and meiotic recombination with progression through the first meiotic cell division in mouse. Abstract Full Text PDF Supplementary Materials Scaling, rotation, and channeling behavior of helical and skyrmion spin textures in thin films of Te-doped Cu 2 OSeO 3 By M.-G. Han , J. A. Garlow , Y. Kharkov , L. Camacho , R. Rov , J. Sauceda , G. Vats , K. Kisslinger , T. Kato , O. Sushkov , Y. Zhu , C. Ulrich , T. Söhnel , J. Seidel 27 Mar 2020 : eaax2138 Open Access CCBY-NC We report on scaling, rotation, and channeling behavior of helical and skyrmion spin textures in thin films of Te-doped Cu 2 OSeO 3 . Abstract Full Text PDF Supplementary Materials Light-triggered topological programmability in a dynamic covalent polymer network By Weike Zou , Binjie Jin , Yi Wu , Huijie Song , Yingwu Luo , Feihe Huang , Jin Qian , Qian Zhao , Tao Xie 27 Mar 2020 : eaaz2362 Open Access CCBY-NC Topological isomerization provides an infinite assembly of arrays with distinct properties isomerized from a matrix polymer. Abstract Full Text PDF Supplementary Materials High-frequency rectification via chiral Bloch electrons By Hiroki Isobe , Su-Yang Xu , Liang Fu 27 Mar 2020 : eaay2497 Open Access CCBY-NC Engineering quantum crystals realizes high-frequency rectifiers by rational material design. Abstract Full Text PDF Supplementary Materials Biomimetic human small muscular pulmonary arteries By Qianru Jin , Anil Bhatta , Jayson V. Pagaduan , Xing Chen , Hoku West-Foyle , Jiayu Liu , Annie Hou , Dan Berkowitz , Scot C. Kuo , Frederic B. Askin , Thao D. Nguyen , David H. Gracias , Lewis H. Romer 25 Mar 2020 : eaaz2598 Open Access CCBY-NC Biofabricated mass-producible arteries containing layered and aligned cells and matrix exhibit enhanced cellular function. Abstract Full Text PDF Supplementary Materials The insulator functions of the Drosophila polydactyl C2H2 zinc finger protein CTCF: Necessity versus sufficiency By Olga Kyrchanova , Oksana Maksimenko , Airat Ibragimov , Vladimir Sokolov , Nikolay Postika , Maria Lukyanova , Paul Schedl , Pavel Georgiev 25 Mar 2020 : eaaz3152 Open Access CCBY-NC CTCF sufficiency depends on various combinations of architectural proteins. Abstract Full Text PDF Supplementary Materials Isolation of an elusive phosphatetrahedrane By Martin-Louis Y. Riu , Rebecca L. Jones , Wesley J. Transue , Peter Müller , Christopher C. Cummins 25 Mar 2020 : eaaz3168 Open Access CCBY Extreme strain eased with P-incorporation. Abstract Full Text PDF Supplementary Materials Slow slip source characterized by lithological and geometric heterogeneity By Philip M. Barnes , Laura M. Wallace , Demian M. Saffer , Rebecca E. Bell , Michael B. Underwood , Ake Fagereng , Francesca Meneghini , Heather M. Savage , Hannah S. Rabinowitz , Julia K. Morgan , Hiroko Kitajima , Steffen Kutterolf , Yoshitaka Hashimoto , Christie H. Engelmann de Oliveira , Atsushi Noda , Martin P. Crundwell , Claire L. Shepherd , Adam D. Woodhouse , Robert N. Harris , Maomao Wang , Stuart Henrys , Daniel H.N....